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A list of experiments that relate adult hippocampal neurogenesis to behavior


The list as a Google spreadsheet (also excel | HTML | RSS feed of updates)
List last updated 3/9/2011.

I’ve always enjoyed making lists. As a kid I can remember writing lists of rhyming words, lists of all the Ocean Pacific clothes I owned, lists of all the people I knew. Many years later, I hope I’ve now made a list that is actually useful.

Adult neurogenesis is now undisputed. Pretty much on a weekly basis there is a new paper that examines both levels of adult hippocampal neurogenesis and behavior, attempting to draw a functional connection. The good news is that the argument for a behavioral function for adult neurogenesis continues to get stronger. The bad news is that there’s a massive pileup of data, and it’s becoming hard to filter through the relevant studies – first you have to find them amongst the 1000+ studies of adult neurogenesis. Then you have to read them. What behaviors are examined? Is there an effect of reducing or enhancing neurogenesis? What method is used to manipulate neurogenesis? What do other studies find that performed a similar analysis? Continue reading A list of experiments that relate adult hippocampal neurogenesis to behavior

Cell Nov. 13, 2009: Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory

Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory

Kitamura et al. (2009) Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory. Cell. 139:814-827.

It’s great to see this paper finally in print. At SFN 2008 the authors had a poster that generated a lot of excitement, at least in our circles.  And the poster was quite a sight: there was such a profusion of data that the poster poured off the easel, nearly reaching the floor. With 27 (!) supplemental figures in the final article, one has to wonder if this is the final straw that led to this article.

The authors use an ingenious approach to address an idea that has been floating around for a while: that adult neurogenesis regulates memory turnover in the hippocampus. Continue reading Cell Nov. 13, 2009: Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory