Archive for the 'dentate gyrus' tag

Virus: a new tool for generating pretty pictures

Now that I have something to show for it, let this be a formal announcement that I’ve returned to Toronto to join Paul Frankland’s lab (and therefore the larger Josselyn-Frankland group). I’ve always liked their work and one of the techniques I’m excited to learn is the use...
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In press: The neurogenesis-depression hypothesis, confirmed.

The idea that adult neurogenesis protects individuals from depression is perhaps the single greatest motivator driving neurogenesis research. Not surprisingly, “neurogenesis depression” is the most common behavioral keyword that brings people to this blog (followed closely by...
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#SFN10 Intinerary Pt. 3 – Mossy Fibers!

…and now for what is probably my final pre-SFN post. Posters dealing with mossy fiber function! Read more

SFN2010 Itinerary Pt. 1

I have 62 items in my itinerary and I expect to add to it in the following weeks. There are always great presentations I find out about last minute and undoubtedly others that never see the light of (my) day. So fill me in if you have any tips. It’s not always the data that’s the most...
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Pattern separation: 370,000,000 papers 2050?

If you’ve been paying attention to the adult hippocampal neurogenesis literature at all, you noticed that “pattern separation” is gaining popularity as a research topic. A few quick searches on Pubmed confirm that a trend is indeed afoot.  For the years prior to 1999, only 15 Pubmed-indexed...
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Do new neurons go through a critical period and then retire, never to be used again?

And here we have the latest, craziest hypothesis of granule cell function. Crazy not because the authors have lost their minds but because the story of the dentate gyrus, where adult neurogenesis occurs, is becoming more peculiar every day. The underlying premise of this paper by Alme et al....
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