Tag Archives: action potential

Are new neurons really more excitable? (yes)

ResearchBlogging.orgSome facts on neuronal excitability:

  1. Excitable: the ability to fire action potentials.
  2. More excitable: fires action potentials, but more.
  3. More LTP: not the same as more excitable.
  4. Less inhibition: also not the same as more excitable, though the two may go hand in hand.
  5. The Scholarpedia page on neuronal excitability, which was last modified on 13 August 2009, has been accessed 49,025 times, and contains no information (peer review is slow).

One of the claims that is often made is that adult-born neurons are more plastic and more excitable than older neurons.  This despite there being little evidence (until recently) that new neurons indeed are more excitable. But, hey, “excitable” sounds great alongside “plastic”. The Schmidt-Hieber paper did show that new neurons are more excitable, though it wasn’t their main focus and it is only occasionally referenced as evidence for greater excitability.

My misunderstanding that there are no thorough investigations of new neuron excitability was brought to an end recently when I was fortunate to have an infant-free moment (In which I was able to read two papers in the same evening, plus an entire New Yorker article over breakfast. Amazing.) One of the papers was Reliable Activation of Immature Neurons in the Adult Hippocampus by Mongiat et al. from Alejandro Schinder’s lab, which I really should have read long ago. Continue reading Are new neurons really more excitable? (yes)