Comments on: In press: The neurogenesis-depression hypothesis, confirmed. http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/?utm_source=rss&utm_medium=rss&utm_campaign=in-press-the-neurogenesis-depression-hypothesis-confirmed New neurons in the adult brain. How they work and what they're good for. Wed, 09 May 2012 20:44:23 -0600 http://wordpress.org/?v=2.8.5 hourly 1 By: Sylwia Koricka http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/comment-page-1/#comment-6626 Sylwia Koricka Tue, 28 Feb 2012 10:13:10 +0000 http://www.functionalneurogenesis.com/blog/?p=1239#comment-6626 The comment about chronic stress reducing neurogenesis isn't a speculation, isn't it? Actually, from my experience, most of studies investigating reduced neurogenesis and disregulation of HPA axis uses daily maternal separation as a chronic stress model... or do you view it differently? The comment about chronic stress reducing neurogenesis isn’t a speculation, isn’t it? Actually, from my experience, most of studies investigating reduced neurogenesis and disregulation of HPA axis uses daily maternal separation as a chronic stress model… or do you view it differently?

]]> By: Jason Snyder http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/comment-page-1/#comment-5186 Jason Snyder Tue, 18 Oct 2011 04:28:45 +0000 http://www.functionalneurogenesis.com/blog/?p=1239#comment-5186 I think one issue that clouds the interpretation of that study is the fact that a number of subjects were excluded for having too much neurogenesis... I think one issue that clouds the interpretation of that study is the fact that a number of subjects were excluded for having too much neurogenesis…

]]> By: david yates http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/comment-page-1/#comment-5133 david yates Sat, 15 Oct 2011 14:59:51 +0000 http://www.functionalneurogenesis.com/blog/?p=1239#comment-5133 Has Reif et al http://nervenklinik.uk-wuerzburg.de/fileadmin/uk/psychiatrie/Dokumente/Forschung/Psychiatric_Neurobiology_and_Bipolar_Disorder_Program/Adult_neurogenesis_in_schizophrenia Reif et al 2006 been forgotten , demolished, rejected, not replicated, found wanting, or just ignored Has Reif et al
http://nervenklinik.uk-wuerzburg.de/fileadmin/uk/psychiatrie/Dokumente/Forschung/Psychiatric_Neurobiology_and_Bipolar_Disorder_Program/Adult_neurogenesis_in_schizophrenia
Reif et al 2006

been forgotten , demolished, rejected, not replicated, found wanting, or just ignored

]]> By: Krishna http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/comment-page-1/#comment-4873 Krishna Tue, 27 Sep 2011 18:36:10 +0000 http://www.functionalneurogenesis.com/blog/?p=1239#comment-4873 HI Jason, I thought much the same. Even though there is quite some amount of supportive data suggesting more=better and less=bad. I agree it may not be all that simple. More could mean encryption of a 'bad context' and less might just be adaptation of some sort in some cases. HI Jason,
I thought much the same. Even though there is quite some amount of supportive data suggesting more=better and less=bad. I agree it may not be all that simple. More could mean encryption of a ‘bad context’ and less might just be adaptation of some sort in some cases.

]]> By: Sil http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/comment-page-1/#comment-4811 Sil Thu, 22 Sep 2011 14:29:00 +0000 http://www.functionalneurogenesis.com/blog/?p=1239#comment-4811 Enjoyed the paper...and your review was fun too (nice linking to the blog). If you haven't seen it yet, I found this article interesting: http://www.ncbi.nlm.nih.gov/pubmed/21878528 Basically its saying that running is a critical part of environmental environment's effects on neurogenesis. I'd be interested to know if running/swimming also underlies the effects of other treatments (such as water maze training, etc.) too. I'm wondering if there is more of a common mechanism and if these stimuli are more similar than we realize. Enjoyed the paper…and your review was fun too (nice linking to the blog).

If you haven’t seen it yet, I found this article interesting:
http://www.ncbi.nlm.nih.gov/pubmed/21878528

Basically its saying that running is a critical part of environmental environment’s effects on neurogenesis. I’d be interested to know if running/swimming also underlies the effects of other treatments (such as water maze training, etc.) too. I’m wondering if there is more of a common mechanism and if these stimuli are more similar than we realize.

]]> By: Jason Snyder http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/comment-page-1/#comment-4609 Jason Snyder Tue, 06 Sep 2011 21:47:28 +0000 http://www.functionalneurogenesis.com/blog/?p=1239#comment-4609 Hi Krishna - increasing neurogenesis could help, though I've <a href="http://www.functionalneurogenesis.com/blog/2010/04/increased-neurogenesis-is-not-necessarily-the-opposite-of-reduced-neurogenesis/" rel="nofollow">speculated before</a> on the possibility that the effects of increasing neurogenesis may not be as simple as being the opposite of the effects of decreasing it. On the other hand, I don't think environmental enrichment or exercise can really be a bad idea! Hi Krishna – increasing neurogenesis could help, though I’ve speculated before on the possibility that the effects of increasing neurogenesis may not be as simple as being the opposite of the effects of decreasing it. On the other hand, I don’t think environmental enrichment or exercise can really be a bad idea!

]]> By: Paul Luu http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/comment-page-1/#comment-4291 Paul Luu Wed, 10 Aug 2011 19:29:50 +0000 http://www.functionalneurogenesis.com/blog/?p=1239#comment-4291 Congrats on the paper Jason! Don't forget the little guys when you become a faculty member. Congrats on the paper Jason! Don’t forget the little guys when you become a faculty member.

]]> By: Krishna Vadodaria http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/comment-page-1/#comment-4257 Krishna Vadodaria Sat, 06 Aug 2011 20:41:00 +0000 http://www.functionalneurogenesis.com/blog/?p=1239#comment-4257 Hi Jason, Great blog, and congratulations on the paper! I used to work with models of depression/ADTs and look at adult neurogenesis. This paper is great, as a big open question is answered, and a much needed link is established. What are you thoughts in the other direction, with enriched environment or exercise in terms helping this neurogenic buffer and helping combat stressful stimuli? Best wishes, Krishna Hi Jason,

Great blog, and congratulations on the paper! I used to work with models of depression/ADTs and look at adult neurogenesis. This paper is great, as a big open question is answered, and a much needed link is established.
What are you thoughts in the other direction, with enriched environment or exercise in terms helping this neurogenic buffer and helping combat stressful stimuli?

Best wishes,
Krishna

]]> By: Brains that can’t grow new neurons are vulnerable to depression | Nutrition News http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/comment-page-1/#comment-4234 Brains that can’t grow new neurons are vulnerable to depression | Nutrition News Thu, 04 Aug 2011 16:16:32 +0000 http://www.functionalneurogenesis.com/blog/?p=1239#comment-4234 [...] growth and depression is not just coincidental but actually causal, according to study leader Jason Snyder of the National Institute of Mental [...] [...] growth and depression is not just coincidental but actually causal, according to study leader Jason Snyder of the National Institute of Mental [...]

]]> By: Karl Lanocha, MD http://www.functionalneurogenesis.com/blog/2011/07/in-press-the-neurogenesis-depression-hypothesis-confirmed/comment-page-1/#comment-4232 Karl Lanocha, MD Thu, 04 Aug 2011 16:00:38 +0000 http://www.functionalneurogenesis.com/blog/?p=1239#comment-4232 Since 1965, the dominant theory for both the causation and treatment of depression has been the "monoamine hypothesis" and many practicing clinicians are uninformed about the "neurogenesis hypothesis". Since transcranial magnetic stimulation (TMS) has become the primary focus of my practice, I have followed the research in this area and am pleased to see that there is now direct evidence to support the "neurogenesis hypothesis". As demonstrated by Ueyama and others (http://www.ncbi.nlm.nih.gov/pubmed/21265939), like antidepressant medication, TMS appears to produce its antidepressant effects by stimulating hippocampal neurogenesis indirectly via stimulation of the prefrontal cortex. Your paper is an important contribution to a growing body of evidence that is leading to a fundamental shift in thinking about the causation and treatment of depression. Since 1965, the dominant theory for both the causation and treatment of depression has been the “monoamine hypothesis” and many practicing clinicians are uninformed about the “neurogenesis hypothesis”. Since transcranial magnetic stimulation (TMS) has become the primary focus of my practice, I have followed the research in this area and am pleased to see that there is now direct evidence to support the “neurogenesis hypothesis”. As demonstrated by Ueyama and others (http://www.ncbi.nlm.nih.gov/pubmed/21265939), like antidepressant medication, TMS appears to produce its antidepressant effects by stimulating hippocampal neurogenesis indirectly via stimulation of the prefrontal cortex. Your paper is an important contribution to a growing body of evidence that is leading to a fundamental shift in thinking about the causation and treatment of depression.

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